Senior manager principal software engineer clinical pharmacology

Working with Us
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.


Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .



Position: Senior Manager, Principal Software Engineer



Location : Cambridge, MA, and Lawrenceville, NJ



Working with Us
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.


Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us



Position Summary



The Principal Software Engineer will lead the design, development, and deployment of innovative software and data platforms supporting Clinical Pharmacology & Pharmacometrics within BMS R&D. This role partners closely with computational scientists and IT teams to enable advanced analytics, modeling, simulation, and workflow optimization, leveraging cloud, HPC, AI/ML, and modern data technologies to accelerate drug development and translational science.



Key Responsibilities

• Support deployment and operation of AI/ML models, simulation tools, and dashboards for scientific users.
• Lead the integration of HPC, cloud, and Kubernetes-based compute environments; optimize parallelization and resource utilization.
• Collaborate with domain scientists, IT, and other stakeholders to gather requirements and translate scientific workflows into robust technical solutions.
• Drive continuous improvement through automation, system upgrades, and stakeholder feedback.
• Manage platform security, validation, and compliance in coordination with IT and cybersecurity teams.
• Architect, develop, and maintain scalable software systems and data platforms for clinical pharmacology and pharmacometrics use cases.
• Mentor engineers and contribute to best practices (CI/CD, Agile).
• Troubleshoot, monitor, and optimize performance of deployed systems.

Qualifications & Experience

• BS/MS/PhD in Computer Science, Software Engineering, or related field; higher degrees preferred.
• 7+ years hands-on experience in software engineering, ideally in life sciences or healthcare domains.
• Proven track record architecting and delivering production-grade software and data platforms (preferably supporting scientific research, modeling or analytics).
• Experience in cross-functional collaboration in matrixed, stakeholder-driven environments.

Primary Skills

• Developer with programming skills in Python (primary) and R, integrating with API endpoints in AWS or Google cloud, knowledge of markdown languages such as Quarto/Typst
• Demonstrated success building GenAI applications and agentic workflows, including fine-tuning and deploying LLMs. Proven experience working with LLM-based content ingestion, prompt engineering, and automating content generation involving complex tables, images, special characters, headers, footers, and merged columns to produce new reports from diverse source documents.
• Experience working of cloud services (AWS, Azure, GCP), HPC, Kubernetes, and parallel/distributed computing.
• Familiarity with software validation, compliance, and best practices in regulated environments.
• Understand all aspects of software development lifecycle
• Understand various SDLC methodologies (Agile, Scrum, Waterfall etc.)
• Familiarity with MATLAB, WebAPP
• Excellent problem-solving, communication, and stakeholder engagement skills.

Additional Skills:

• knowledge of vector databases and graph RAG would be a plus
• Experience with Posit Workbench/RStudio Server, NAS integration, or similar collaborative scientific platforms.
• Knowledge of QSP, PBPK, PK/PD modeling or pharmaceutical R&D workflows.
• Experience implementing robust access controls, NFS, ACLs, and enterprise authentication.
• Agile and DevOps methodologies, CI/CD, and automation scripting (e.g., Bash, Ansible, CFT, Terraform).

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.



Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients' lives through science™, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.



On-site Protocol
BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:


Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.


BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [email protected]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.


BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.


BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.


If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information:


Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.


If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.



Compensation Overview:


Cambridge Crossing: $165,120 - $200,088
Princeton - NJ - US: $150,110 - $181,898


The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.


Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit


Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.

Work-life benefits include:


Paid Time Off

• US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
• Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays

Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.


All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

• Eligibility Disclosure: T he summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.



On-site Protocol


BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:


Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.



Supporting People with Disabilities


BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [email protected] . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement.



Candidate Rights


BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.


If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information:



Data Protection


We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at .


Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.


If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at [email protected] . Please provide the Job Title and Requisition number so we can review. Communications related to your application should not be sent to this email and you will not receive a response. Inquiries related to the status of your application should be directed to Chat with Ripley.


R1597734 : Senior Manager, Principal Software Engineer, Clinical Pharmacology and Pharmacometrics