Associate Principal Scientist, Mass Spectrometry

At Insmed, every moment and every patient counts - and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you'll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person's contributions to meaningful progress. That commitment has earned us recognition as Science magazine's No. 1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK.

For patients, for each other, and for the future of science, we're in. Are you?

About the Role:
We're looking for a highly motivated and experienced Mass Spectrometry Scientist to help us expand what's possible for patients with serious diseases. Reporting to the Executive Director, Research, the Associate Principal Scientist, Mass Spectrometry will play a critical role in elucidating mechanisms of action (MOA) and identifying biomarkers for novel protein inhibitors and therapeutic programs.

The successful candidate will apply advanced mass spectrometry-based approaches to characterize proteomic and metabolomic changes in biological systems following inhibitor or therapeutic treatment. This work will enable the identification of protein-based biomarkers associated with therapeutic activity and contribute to a deeper understanding of drug effects at the cellular and system levels, ultimately supporting the advancement of new therapeutics.

What You'll Do:

In this role, you'll have the opportunity to develop, optimize, and implement advanced mass spectrometry workflows, including DDA and DIA, to screen for and identify protein-based biomarkers associated with therapeutic activity. You'll also:

• Design and execute quantitative mass spectrometry experiments to measure low-abundance proteins in complex biological matrices, including plasma, tissues, and cerebrospinal fluid (CSF).
• Design and conduct experiments to identify and characterize changes in the proteome or metabolome following inhibitor or therapeutic treatment of relevant biological samples (e.g., cells, plasma, tissues).
• Apply bioinformatics and data analysis tools to interpret complex datasets and identify relevant proteins, metabolites, and potential biomarkers.
• Collaborate closely with cross-functional stakeholders to ensure timely delivery of high-quality data aligned with project objectives.
• Prepare and present research findings at internal meetings and external scientific conferences and contribute to the preparation of manuscripts and scientific publications.
• Stay current with emerging advances in mass spectrometry technologies and methodologies, particularly as applied to proteomics, metabolomics, and biomarker discovery in drug research.

Who You Are:

You must have a PhD in Chemistry, Biochemistry, or a related scientific discipline, with a strong emphasis on mass spectrometry-based proteomics, metabolomics, and protein quantification. Additionally, you have:

• 10+ years of hands-on industry experience applying advanced mass spectrometry techniques in proteomics and protein quantification.
• Demonstrated experience with LC-MS system operation, maintenance, and troubleshooting.
• Strong understanding of cellular biology and the impact of protein inhibition on proteomic and metabolic pathways.
• Proven ability to analyze, interpret, and communicate complex scientific data effectively.
• Excellent written and verbal communication skills, with experience in scientific documentation and publication.
• Strong work ethic, self-motivation, and a collaborative, team-oriented mindset.
• Commitment to strict adherence to environmental, health, and safety (EHS) guidelines.

Where You'll Work

This role is based out of our Bridgewater, NJ office and requires full-time, in-person presence to support hands-on collaboration, access specialized equipment, and/or operational needs.

Travel Requirements

Minimal travel expected

#LI-MM1

Pay Range:
$155,000.00-201,500.00 Annual

Life at Insmed

At Insmed, you'll find a culture as human as our mission-intentionally designed for the people behind it. You deserve a workplace that reflects the same care you bring to your work each day, with support for how you work, how you grow, and how you show up for patients, your team, and yourself.

Highlights of our U.S. offerings include:

• Comprehensive medical, dental, and vision coverage and mental health support, annual wellbeing reimbursement, and access to our Employee Assistance Program (EAP)
• Generous paid time off policies, fertility and family-forming benefits, caregiver support, and flexible work schedules with purposeful in-person collaboration
• 401(k) plan with a competitive company match, annual equity awards, and participation in our Employee Stock Purchase Plan (ESPP), and company-paid life and disability insurance
• Company Learning Institute providing access to LinkedIn Learning, skill building workshops, leadership programs, mentorship connections, and networking opportunities
• Employee resource groups, service and recognition programs, and meaningful opportunities to connect, volunteer, and give back

Eligibility for specific programs may vary and is subject to the terms and conditions of each plan.

Current Insmed Employees: Please apply via the Jobs Hub in Workday.

Insmed Incorporated is an Equal Opportunity employer. We do not discriminate in hiring on the basis of physical or mental disability, protected veteran status, or any other characteristic protected by federal, state, or local law. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.

Insmed is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities. To request reasonable accommodation to participate in the job application or interview process, please contact us by email at [email protected] and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Applications are accepted for 5 calendar days from the date posted or until the position is filled.