Manufacturing Associate (Upstream & Downstream)

Job Title: Manufacturing Associate (Upstream & Downstream)
Location: Princeton Area, New Jersey
Hours / Schedule: Full-time, shift flexibility required (day, evening, overnight rotation possible, overtime available based on production needs)
Type: Temp-to-Hire (potential direct opportunity for the right fit)

SUMMARY
Support both Upstream and Downstream manufacturing operations in a cGMP-compliant environment. This role provides hands-on experience throughout the biologics production process — from cell culture to protein purification.

REQUIREMENTS

• High School Diploma or Associate’s Degree with 1–5 years of relevant GMP experience
  OR
• Bachelor’s Degree in Biotechnology, Biochemistry, Microbiology, Chemical Engineering, or related field
• 1–5 years of GMP experience in Pharmaceuticals, Biologics, Medical Devices, Cleanroom, or Chemical Processing environments
• Comfortable working in sterile/cleanroom settings and following strict protocols
• Strong interest in cross-functional manufacturing roles with growth potential
• Open to flexible hours outside of a standard 8am–5pm schedule
• Open to Temp-to-Hire employment
• Ability to stand for long periods and lift up to 50 lb
• Strong attention to detail and documentation skills
• Willingness to cross-train and support evolving production needs

Upstream

• Familiarity with aseptic techniques and bioreactor operation
• Experience with cell culture, buffer / media prep

Downstream

• Understanding of chromatography, TFF (Tangential Flow Filtration), viral filtration
• Hands-on experience in cleanroom/purification operations

RESPONSIBILITIES

Upstream Manufacturing

• Prepare media and buffers
• Thaw vials, expand seed trains, and operate bioreactors (fed-batch/perfusion)
• Monitor/document cell growth and bioreactor parameters
• Support cell harvest through clarification and filtration

Downstream Manufacturing

• Conduct chromatography operations (AKTA or similar systems)
• Perform Tangential Flow Filtration (TFF) and diafiltration
• Execute viral filtration procedures
• Support cleanroom-based final fill operations

General Duties

• Adhere to cleanroom, gowning, and aseptic protocols
• Maintain GMP-compliant documentation
• Clean and sanitize production equipment
• Collaborate with Quality, Engineering, and Logistics teams

#M3

Ref: #558-Scientific

System One, and its subsidiaries including Joulé, ALTA IT Services, TeamPeople, and Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.

System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.