Immuno-oncology Intern

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking an Immuno-oncology Intern as part of the Research & Early Development team based in Piscataway, NJ .

Role Overview

The intern candidate will evaluate the functional and cytotoxic potential of CAR-T cells and other immune cells using various assays, with a particular focus on cellular assay and cytokine analysis. They will also investigate the correlation between the polyfunctional index and serial cytotoxicity across multiple donors.

Key Responsibilities

• Perform transfection for virus production and conduct ELISA- or flow cytometry-based virus titration.
• Conduct PBMC transduction and functional evaluation.
• Carry out multiple assays, including cytokine analysis.
• Perform tumor killing assays using Incucyte or flow cytometry.
• Analyze and interpret experimental data, present results to the manager, and share findings in group meetings.
• Work under the supervision of the manager and senior team members.
• Independently carry out routine experimental work, basic data analysis, and documentation according to established protocols.
• Suggest technical approaches or troubleshooting ideas, but all experimental plans, data interpretation, and project decisions require review and approval by the manager or designated mentor.
• Decisions related to project scope, timelines, resources, or strategic direction will remain under management oversight.

Requirements

• Enrollment in a bachelor’s or master’s program in Biology, Immunology, Biotechnology or a related field.
• Lab experience and good practice of basic techniques (e.g., pipetting, microscopy, cell culture).
• Familiarity or conceptual understanding of transfection/transduction, flow cytometry, ELISA, and other immunoassays.
• Understanding of biological concepts and interests related to the internship focus (e.g., genetics, immunology, cell and molecular biology).
• Strong communication and teamwork skills as well as analytical and problem-solving abilities.
• Attention to detail for lab work and data recording.
• Knowledge of data analysis tools (e.g., Excel, Graphpad Prism, R, Python).
• Languages preferred: English & Mandarin.

Please note: These benefits are offered exclusively to permanent full-time employees. Contract employees are not eligible for benefits through Legend Biotech.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.

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